In normal pregnancy, neutrophils induce protective immunity against extracellular microbes in the uterus, but an excess of activated neutrophils, as found in PE, may enhance the release of typical inflammatory mediators in PE, such as ROS, TNF-α, and myeloperoxidase (MPO), causing hypertension and endothelial dysfunction [50,51,52]. Here, MPO is linked to hypertensive disorder.