Here, we have analyzed the DNA damage-inducing potential and methylation-changing capability of three carbazoles, PK083, PK9320, and PK9323, in human breast adenocarcinoma cells (MCF-7) to evaluate their potential use as “anticancer (epi)drugs” in a combinatorial molecular therapy [26], in addition to their reported action as Y220C mutant p53 reactivators [15,16]. Here, TP53 is linked to breast adenocarcinoma.