FGF21 and type 2 diabetes mellitus: Figure 1 shows the optimal cut-off value of FGF-21 to predict AS of T2DM patients was 250.15 pg/mL with AUC 0.706 (95% C.I. 0.619–0.782), sensitivity 55.56% (95% C.I. 40.0–70.4%) and specificity 83.53% (95% C.I. 73.9–90.7%), respectively.