Subsequently, another cohort study conducted in DM patients with valid FGF-21 data (9697 patients), Ong et al. showed that serum FGF-21 levels were higher in patients who were older; exhibiting higher BMI, TG levels, and creatinine levels; and had a prior history of CVD; furthermore, FGF-21 levels were associated with unsatisfactory overall CVD outcomes [12]. Here, FGF21 is linked to diabetes mellitus.