TNFSF10 and cancer: Based on our findings [42,96], we suggest that the activation of DR5 normally favors the formation of the DISC, resulting in induction of apoptosis or anoikis as well as other potential biological consequences; this will not only lead to direct killing of detached cancer cells (e.g., via anoikis or TRAIL/DR5-mediated immune surveillance) but also restrict the formation of another complex named the metastasis and invasion signaling complex (MISC), eventually resulting in the suppression of cancer cell invasion and metastasis.