Given that TRAIL induces MCP1 expression in TRAIL-resistant cancer cells [88], it is plausible to speculate that increased MCP1 expression and release is likely to induce MCPIP1 expression; this, in turn, downregulates the levels of DR5 including cell surface DR5, promoting the formation of MISC and subsequent invasion and metastasis of cancer cells (Figure 1A). This evidence concerns the gene CCL2 and cancer.