TNFSF10 and neoplasm: In a renal cell carcinoma orthotopic tumor model with aggressive primary tumors and lung metastases detectable by day 7, intra-renal administration of Ad5mTRAIL+CpG, an adenovirus-encoded TRAIL/CpG immunotherapy regimen, on day 7 led to an influx of effector phenotype CD4 and CD8 T cells into the kidney by day 12 and regression of established primary renal tumors.