KRAS and cancer: There was a study demonstrating that mDR and human DR5 promote K-Ras-driven cancer progression, invasion, and metastasis [56]; these results are contradictory to their previous findings using an H-Ras-driven skin carcinogenesis model [40] and to our findings with several human cancer cell lines such as A549, H460, and HCT116, which all have mutant K-Ras [42].