TNFRSF10B and cancer: Given that TRAIL induces MCP1 expression in TRAIL-resistant cancer cells [88], it is plausible to speculate that increased MCP1 expression and release is likely to induce MCPIP1 expression; this, in turn, downregulates the levels of DR5 including cell surface DR5, promoting the formation of MISC and subsequent invasion and metastasis of cancer cells (Figure 1A).