NPSR1 and obesity due to melanocortin 4 receptor deficiency: Interestingly, the Asn107Ile SNP revealed not only to affect the in vitro properties of the NPSR, but also a gender-specific association of this genotype with panic disorder, mainly observed in male patients [32] and recently, a study performed in male obese Pakistani individuals, highlighted the presence of this SNP as a risk factor for the development of obesity [20].