Considering the important influence of orexin-A in the regulation of feeding behavior and that OX1R antagonists represent potential pharmacological tools to treat obesity and aberrant eating patterns [10,106,107,108], future investigations should elucidate if the NPS effect on food intake is, at least, partially mediated by neuronal changes in orexin transmission. This evidence concerns the gene HCRT and obesity due to melanocortin 4 receptor deficiency.