IGF2 protein and mRNA were shown to be significantly increased in metastatic PPGL, which is consistent with other studies investigating the relationship between IGF2, miR-483-5p, and adrenocortical carcinoma, where miR-483-5p is also overexpressed in comparison to benign adrenocortical adenomas [70,79]. This evidence concerns the gene IGF2 and adrenal cortex adenoma.