In particular, it has been reported that insulin-induced tyrosine phosphorylation of IRβ was 26–29% lower in the kinase domain (Y1146, Y1150, and Y1151) and 34–58% lower at the IRS1 docking site (Y960) in AD brains compared to age matched controls, even at the same levels of IR and the IR phosphatase PTP1B proteins [20]. Here, INSR is linked to Alzheimer disease.