Interestingly, when we compared MM patients with and without osteolytic lesions at diagnosis, significantly higher levels of IL6 -median (range) of 48 (0–32) vs. 13 (13–400) pg/mL, respectively (p = 0.001)- and BALP -median (range) of 594 (211–4201) vs. 387 (197–739) pg/mL, respectively (p = 0.05)- were detected among MM patients that had osteolytic lesions. Here, IL6 is linked to Miyoshi myopathy.