TNFSF11 and Miyoshi myopathy: In turn, upregulation of the RANKL-receptor activator of nuclear factor κ B ligand-pro-osteoclastogenic factor, in parallel to decreased osteoprotegerin (OPG) levels, have been described in BM of MM [11,12,13,14,15] and also MGUS patients [16], in association with an accelerated turnover of BM osteoblasts and increased bone alkaline phosphatase (BALP) and RANKL levels in serum of these patients [17,18].