In line with these findings, Martín-Ayuso et al. [28] have previously shown enhanced ex vivo secretion (vs HD) of proinflammatory cytokines, such as IL6, IL8, IL12, TNFα and IL15 by DC and ncMo in MGUS and MM patients in the presence of undetectable IL1β serum levels. This evidence concerns the gene TNF and Miyoshi myopathy.