Despite this, an increased RANKL/OPG ratio was observed in MM (either in presence or absence of bone osteolytic lesions) vs. SMM patients -median (range) of 3 (0.8–4) vs. 1 (0.2–2), p ≤ 0.01- (Figure 4G). Here, TNFSF11 is linked to Miyoshi myopathy.