Thus, MGUS and SMM patients showed increased IL1β levels -median (range)- in plasma −2.3 (0.0–14) and 4.1 (0.0–9) pg/mL vs. undetectable levels in HD, (p = 0.007 and p = 0.01), respectively-, while these were within the normal range (e.g., usually undetected) in MM −0.0 (0.0–21) pg/mL, vs. HD p = 0.3-. The gene discussed is IL1B; the disease is Miyoshi myopathy.