Other authors evidenced that the TCF7L2 variant is located in a binding site of the FOXA2 gene, encoding a transcriptional factor that is involved in pancreatic and hepatic development [108], as well as in islet-selective open chromatin regions that regulate gene expression [109], allowing them to hypothesize a possible role of this variant in the early onset of diabetes. Here, TCF7L2 is linked to diabetes mellitus.