Another study conducted proteomic analyses and revealed that trans10-cis12 CLA showed pro-atherogenic effects and induced insulin resistance in atherosclerosis-prone apolipoprotein E-deficient (Apoe−/−) mice, while cis9-trans11 CLA was anti-atherogenic and induced heat shock protein 70 kDa expression [40]. The gene discussed is APOE; the disease is Insulin resistance.