BRAF and metastatic melanoma: In this study, we created BRAF-mutant lung metastatic melanoma cells (A375LM5IF4g/Luc) and demonstrated that DETD-35 is more potent at inhibiting A375LM5IF4g/Luc activity in vitro than its parental compound DET, and that GSH depletion and ROS accumulation are important upstream events.