IFNA1 and Zika virus infectious disease: However, it is conceivable that sfRNAs may be involved in ZIKV efficient infection and neuro-pathogenicity in vivo, since these events have been related to impairment of the IFN response in several mouse models of ZIKV infection [204,259,260,261,262] and in other scientific evidence obtained from patients [206,235,263,264].