TLR3 and Zika virus infectious disease: IFNs are produced after ZIKV entry into target cells by recognition of the viral +ssRNA genome into the endosomal compartments by the membrane associated Toll-like receptors (TLR)-3 or -7 [191,192,193], as further confirmed by specific, small interference RNA (siRNA) knock-down of TLR-3 in human skin cells that strongly favors ZIKV infection [180].