XBP1 and Zika virus infectious disease: Thus, ZIKV infection activates the expression of proteins related to the UPR pathway in mouse neural cells, such as IRE1 (inositol-requiring enzyme)-XBP1 (X-box binding protein 1) and ATF6 (activating transcription factor 6) [292], also observing the upregulation of several RNA transcripts of genes related to the autophagy function and pathway, such as atf4, gadd34, chop, and edem-1 genes.