CD4 and Zika virus infectious disease: Some studies on the role of T cells in ZIKV infection indicate that CD8+ T cells are important for controlling the viral load (viremia) of ZIKV, as depletion of CD8+ T cells in mice resulted in enhanced virus replication [312], whereas CD4+ T cells presented a Th1 profile that produces the antiviral IFN-γ together with TNF-α, and interleukin 2 (IL-2) [312].