RAF1 and hyperinsulinemic hypoglycemia, familial, 4: Additionally, in IFN-induced cells, ZIKV NS5 expression results in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 in humans but not in mice, and also affects STAT1 phosphorylation levels, suppressing INF-mediated JAK/STAT signal transduction [244,245], which show that ZIKV-induced disease takes advantage of NS5-promoted IFN deficiency.