On the contrary, ZIKV infection upregulates some miRNAs, such as miR-431-5p, together with upregulation of CHOP (C/EBP homologous protein) and GADD34 (growth arrest and DNA damage-inducible 34) genes that are autophagy associated factors [288]. The gene discussed is PPP1R15A; the disease is Zika virus infectious disease.