Figure 2 showed representative images for the immunohistochemistry for HIF-1α and CD34. HIF-1α immunohistochemical expression of tumor cells was significantly higher in CRCs with stroma-high than those with stroma-low (p = 0.035). Moreover, MVD was considerably higher in the stroma-high subgroup than the stroma-low subgroup (p = 0.008). Table 3 shows the correlation between the various elements of TSR and CRCs. However, there was no significant correlation between HIF-1α and MVD (p = 0.108). The gene discussed is HIF1A; the disease is neoplasm.