In summary, this work demonstrates that a newly identified cell surface complex, the PSPN Complex, consisting of the extracellular matrix protein, perlecan, interacting with the cell surface complex Sema3A, plexin A1 and NRP1, plays a key functional role in cell cohesion and dyscohesion in metastatic PCa cells. The gene discussed is PLXNA1; the disease is posterior cortical atrophy.