Intriguingly, highly abundant exosomal miRNAs such as miR-100-5p, miR-21-5p, and miR-139-5p from prostate cancer stem cells increased MMP2, 9, 13 and RANKL expression and enhanced the migration of fibroblasts, contributing to local invasion and pre-metastatic niche formation [90]. This evidence concerns the gene MMP2 and prostate carcinoma.