Intriguingly, Kaplan–Meier survival analysis (online tool: http://kmplot.com, accessed on 2, February, 2021) revealed that the constitutive expression of MMP14 in ΕRα-positive breast cancer patients following systemic treatment (Figure 1A) has the direction to a better probability of relapse-survival (RFS) compared to low MMP14 expression. Here, MMP14 is linked to breast cancer.