In breast invasive ductal carcinoma (IDC) patients, analysis of tissue specimens by IHC revealed that CTSL is expressed in advanced tumor stage patients, CTSB is found in ERα+ tissues with poor disease-free survival (DFS) rates, CTSK is expressed in ERα+/PR+ tumors and, finally, CTSD expression associates with poor prognosis, high incidence of metastasis, especially to the chest, and low DFS rates [181]. The gene discussed is ESR1; the disease is neoplasm.