Among these cytokines, TNF-α and IL-1β could be the critical mediators for development of ConA-induced hepatitis, since TNF-α-deficient mice [4] and NLRP3- and caspase-1-deficient mice that do not produce IL-1β [41] are almost protected from ConA-mediated liver damage. The gene discussed is CASP1; the disease is Hepatitis.