CCL2 and obesity due to melanocortin 4 receptor deficiency: In conclusion, a growing body of experimental data supports the hypothesis that the beneficial effects of curcumin on obesity-related pathologies may be related to the suppression of IL-6, TNFα, IL-1β, and MCP-1 expression from adipocytes, the inhibition of macrophage recruitment in AT, and the inhibition of the inflammatory activity of the NLRP3 inflammasome [89] (Table 2).