MAPT and Alzheimer disease: Moreover, the model shares other typical features of neurodegenerative disorders, such as oxidative stress [25], microglia activation [28], mitochondrial dysfunction [29], progressive pattern of action [22], altered neurotransmission [23,30,31,32], and altered expression of multiple gene groups, including those relevant to Alzheimer’s disease, such as presenilin 1, presenilin 2, amyloid precursor protein, and tau [33,34].