Given the fact that recent evidence indicates that HDACIs also modify non-histone proteins, the role of panobinostat in inhibition of DNMT activity in HCC cell lines was examined by Zopf et al. The results showed significant inhibition of mRNA levels for DNMT1 and DNMT3a, with a transient decrease in these protein levels as well. Here, DNMT1 is linked to hepatocellular carcinoma.