The anticancer agent SFN and the more potent structurally-related dietary isothiocyanates (6-SFN and 9-SFN) inhibited HDAC activity and DNA damage/repair pathways in human colon cancer cells, but not in normal cells, by targeting CtBP-interacting protein (CtIP), which is a key player in homologous recombination (HR) [15]. The gene discussed is HDAC9; the disease is malignant colon neoplasm.