Furthermore, increased ALP staining in osteogenic differentiation media-treated cells were augmented by the addition of native FN, FNIN2-NH2, or FNIN3-NH2, and significant enhancements in osteogenic differentiation were observed when MSCs were treated with FN, FNIN2-NH2, or FNIN2-NH2 as compared with OM treated MSCs (Figure 5). The gene discussed is FN1; the disease is ocular melanoma.