CD38 and breast cancer: However, there was a 7.5-fold increase in CD38 expression in specimens of tumors from hyperglycemic patients as compared to the specimens of tumors from normoglycemic patients (Figure 4c, p = 0.04), but the levels of pro-resolving (EGR2) macrophages marker were decreased 2.4-fold in hyperglycemic tumors (Figure 4d, p = 0.006), suggesting that infiltrating TAMs are more pro-inflammatory in human BC tumors of hyperglycemic patients compared to normoglycemic patients.