INS and type 2 diabetes mellitus: We used three mouse models to study the effects of increased blood glucose levels on mouse BC xenograft growth, miR-467 levels, and inflammation: (1) STZ-induced hyperglycemia that imitates human type 1 insulin-dependent diabetes, (2) genetic model of insulin resistance and type 2 diabetes (Lepr db/db mouse), and (3) a diet-induced insulin resistant and hyperglycemic model, which may be closest to mimicking the human diet-induced metabolic changes observed in the “Western” population.