ESR1 and neoplasm: Further analysis, using this simpler model (Supplementary Materials Statistics, Table S5), indicated that the variance in pathway activity score between patients (σpat) is larger than the variance within a single tumor (σblock) for the WNT and ER pathways (i.e., σpat/σblock > 1), while both variances were comparable for the remaining pathways (Figure 3C, Supplementary Materials Statistics, Table S5).