For the TGFβ and FOXO pathways, activity scores were generally lower in lymph node metastases compared to the PT, with lower FOXO indicating higher PI3K pathway activity; for AR, HH and WNT pathways, activity scores were more frequently higher in lymph node metastases compared to the PT (Figure 5A, Supplementary Materials Statistics, Tables S8–S10). This evidence concerns the gene AR and metastatic malignant neoplasm in the lymph nodes.