TARDBP and amyotrophic lateral sclerosis: Further showing the role of TDP-43 in oxidative stress, Iguchi et al. showed that oxidative stress induced by glutathione depletion led to changes in the C-terminal phosphorylation, fragmentation, insolubilization and cytoplasmic distribution of TDP-43, effects that have been seen in ALS as well as other neurodegenerative diseases.