On the other hand, defective dynamics of actin polymerization leads to abnormal activation of pyrin inflammasome and autoinflammation, as in PAPA syndrome [106,107,108], Familial Mediterranean Fever [108,109,110], Hyper-IgD syndrome [109], and CDC42 deficiency [111,112]. The gene discussed is CDC42; the disease is hyperimmunoglobulinemia D with periodic fever.