Of particular interest are two groups of disorders, respectively characterized by hyperactivation of the PI3K–AKT–mTOR pathway, as autoimmune lymphoproliferative syndrome (ALPS), APDS, immuno-TORpathies [124,125], and by defective function of regulatory T cell functions, such as immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX), CTLA4 deficiency, and LRBA deficiency. The gene discussed is PIK3CD; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.