Thus, actinopathies may predominantly present with phenotypes related to combined immunodeficiency or to autoinflammation, but some disorders may present with mixed phenotypes, as in the case of Wiskott–Aldrich syndrome [10,113], ARPC1B deficiency [114], or WDR1 deficiency (in which, however a defective neutrophil function is associated with the dysregulation of IL-18 instead of IL-1 [115,116]). This evidence concerns the gene IL18 and alpha-actinopathy.