IL1RN and central nervous system cancer: In human glioma samples, myeloid cells isolated from the tumor periphery showed an increased expression of genes coding for cytokines (CCL3, CCL4, TNF) and the pro-inflammatory interleukins (IL1B, IL1A, IL6-R), whereas immune cells isolated from the tumor core upregulated genes involved in angiogenesis (VEGFA, VEGFB) and encoding inhibitors of pro-inflammatory cytokines (IL1RN) [66], indicating the tumor-supportive phenotype of GAMs within a tumor core.