Similarly, in the model of amyotrophic lateral sclerosis (ALS) - mSOD1, microglia showed a reduction of the core microglial genes Tmem119 and P2ry12 [72,76] and upregulated Trem2, Tyrobp, Lpl, and Cst [72]. The gene discussed is TYROBP; the disease is amyotrophic lateral sclerosis.