Immunofluorescence studies of platelet-derived growth factor B (PDGFB)-driven gliomas and GL261 gliomas developing in Cx3cr1GFP+Ccr2RFP+ transgenic mice showed a different location of cells: macrophages (GFP+RFP+) are predominant in the tumor core, while microglia (GFP+RFP-) accumulate in a tumor periphery [51]. Here, PDGFB is linked to central nervous system cancer.