They also restrict cancer-cell-intrinsic MHC class II expression—essential for the recognition of cancer cells by T cells [79] and impair T-cell effector functions and antitumor immunity via cyto-/chemokine-mediated (e.g., IL-1, IL-6, IL-8, GM-CSF) induction of myeloid-derived suppressor cells (MDSCs), regulatory T cells and M2-differentiated tumor-associated macrophages (TAMs) [80,81,82,83,84,85,86,87,88,89] (Figure 1). The gene discussed is CXCL8; the disease is cancer.