Gorlin syndrome, or basal cell nevus syndrome, is a hereditary disease related to the mutations (more than 100 gene mutations have been reported) of patched 1, patched 2 and PTCH2, and SUFU genes, characterized by systemic and diverse developmental abnormalities and neoplastic lesions [162,163,164]. Here, PTCH1 is linked to nevoid basal cell carcinoma syndrome.