Additionally, several variants were previously catalogued as pathogenic (such as the E318K variant in the transcription factor MITF [64]); others affected strong mediators of inherited predisposition to lymphomas (i.e., DOCK8, EXT1, MSH6, and SOS1 [65,66,67,68]), while others have been flagged as pathogenic somatic mutations in cancer, such as NOTCH1 R912W [69,70] and CNOT3 E20K [71,72]. Here, SOS1 is linked to cancer.