PBRM1 and renal cell adenocarcinoma: In the same year, Singla [58] presented comprehensive genetic analyses in PM of the RCC and proved alterations in the PM group associated with a lower aggressiveness (low frequency of BAP1 mutations, which is associated with aggressive disease and a high frequency of PBRM1 loss (>75%), which is associated with less aggressive disease [149,157,158,159] and with a low frequency of copy number alterations associated with aggressiveness, such as 9p, 14q, and 4q loss).