Both PEA/Pol and SF treatment showed an increase in Nrf2 antioxidant activity following DNBS-induced colitis as well as increased MnSOD expression levels, suggesting the involvement of the Nrf2 antioxidant pathway in the mechanism of protection of PEA/Pol compared to the action of um-PEA, which showed only anti-inflammatory effects. This evidence concerns the gene SOD2 and colitis.