To determine the SCG3 expression in the SCLC patients, the PB samples from 26 affected individuals were analyzed and the SCG3 levels were found to be statistically significantly higher in SCLC patients (median 1.32; interquartile range (IQR), 0.00–18.72) compared with samples from HBD (p = 0.038, Mann–Whitney U-test). Here, SCG3 is linked to small cell lung carcinoma.