As REST was first described as a transcriptional, dynamic repressor that blocks the neuroendocrine differentiation in non-neuronal cells of NSCLC, the most probable hypothesis could be that some transcripts restricted by REST, such as SCG3, should also represent specific markers of the YAP1-SCLC subpopulation cells and could serve as predictive markers of response to chemotherapy. This evidence concerns the gene REST and small cell lung carcinoma.