Each of these subtypes is defined by its inter tumor expression levels of the four key transcription regulators: Achaete–Scute Family BHLH Transcription Factor 1 (ASCL1), Neuronal Differentiation 1 (NEUROD1), POU Class 2 Homeobox 3 (POU2F3), and yes–associated protein 1 (YAP1) [5]. The gene discussed is POU2F3; the disease is neoplasm.