To analyze the impact of curcumin on the TME, ex vivo tumor tissues and macrophage cultures were incubated with curcumin, TLR3 ligand PIC, or the combination of both, and supernatants were examined by ELISA with regard to the release of CTL-attracting chemokines CXCL10 and CCL5 and Treg-attracting chemokine CCL22. The gene discussed is TLR3; the disease is neoplasm.