Two years later, cytotoxin-associated gene A (CagA) of Helicobacter pylori (H. pylori) was identified to enhance the expression of c-myc, DNMT3B, enhancer of zeste homolog 2 (EZH2), and to attenuate the expression of miR-26a and miR-101, which resulted in the inhibition of let-7 expression through histone and DNA methylation in H. pylori-related gastritis and GC [92]. The gene discussed is EZH2; the disease is gastric cancer.