PMAIP1 and cancer: Both its derivatives exerted pro-apoptotic action on the breast cancer MCF-7 line, where treatment with 10 nM of 4HPTTNPB resulted in a 10–20-fold increase in the induction of pro-apoptotic markers ATF3, GADD34, BBC3, and NOXA, marking its great potential as an anti-cancer treatment [37].