Li et al. [45] observed that quercetin (2 mg/kg b.w.)administered to pregnant rats with LPS-induced preeclampsia significantly reduced systolic blood pressure, rescued abnormal uteroplacental angiogenic status, decreased the elevated changes of tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio, suppressed the production of cytokine production in the placenta (TNF α, IL-6 and MCP-1), reduced lipid peroxidation by reduction of the MDA level, and ameliorated adverse pregnancy outcomes. This evidence concerns the gene PGF and preeclampsia.