In another study, Zhou et al. [19] observed in lipopolysaccharide-induced preeclampsia in pregnant mice that curcumin at a dose of 100 μg/kg/d i.g. also decreased expression of inflammatory factors such as TNF-α, IL-1β, IL-6 and levels of chemokines such as MCP-1 and MIP-1 and increased the level of phosphorylated Akt by its upregulation in the placenta. This evidence concerns the gene TNF and preeclampsia.