CXCL8 and cancer: These studies used a variety of measurements to determine the extent of biomimicry within in vitro cultures, using a range of criteria including: Genetic expression of angiogenic and matrix remodelling genes, protein synthesis of angiogenic, invasive and matrix remodelling molecules,; morphological basis involving regulators such as expression of hypoxia induced factors, proangiogenic factors, EMT markers, and factors associated with tumour cell stemness; increased IL-8 expression; measured increases in growth of cancer and invasion.