On the other hand, the gene signature coexpressed with BGN, which reflects the majority of GC patients, shown to be enriched in several oncogenic pathways, such as extracellular matrix regulation, angiogenesis, apoptosis, cell adhesion, and positive regulation of cell migration, proteoglycans, focal matrix adhesion, and heparin binding (Figure 2A,B, red). This evidence concerns the gene BGN and gastric cancer.