Here, we could successfully generate a mouse model of obesity as well as hyperglycemia by administering an HFD and then continually administering doxepin to this model so as to promote body weight gain and increase food intake; fatty liver scores; serum ALT and AST levels; liver, kidney, and WAT weights; serum and liver triglyceride levels; and adipocyte size. The gene discussed is GPT; the disease is Hyperglycemia.