IL1B and glomerulonephritis: Similarly, in our treated mice, doxepin caused glomerulonephritis—characterized by the presence of inflammation in renal glomeruli and elevations in renal function index values [76]—as an adverse effect; we noted increased expression of renal inflammatory cytokines (such as IL-1β) in the IHC staining of kidney tissue (Figure S9), along with elevations in serum creatinine and BUN levels in doxepin-treated mice.