MAPK1 and cancer: It has been observed that the E-G350 variant and the variants of the AA sublineage of the E6 oncoprotein of HPV 16 affect the regulation of metabolic reprogramming in cancer, the E-G350 variant through MAPK, and the variants of the sublineage AA by obtaining nutrients through MEK1/ERK1-activated autophagy and by activating MAPK-ERK, MAPK-p38, and PI3K/AKT signaling.