In liver cancer cell lines such as Hep3B, HepG2, JHH5, JHH7, and Huh7, the expression of HK2 has been observed, while in other cancers such as lung, breast, colon, and also in HLF and HH6, liver cancer cell lines are expressed as both HK2 and HK1 [36]. The gene discussed is HK2; the disease is liver cancer.