So-Young Kim and colleagues discovered that curcumin potently inhibited glioma invasion by inhibiting all the MAPK pathways (JNK, p38, ERK), which then suppressed phorbol myristate acetate (PMA)-induced mRNA expression of MMP-1, -3, -9, and -14 in U87MG and U373MG cells [45,46]. Here, MMP1 is linked to central nervous system cancer.