CLEC4E and neoplasm: In accordance with the known involvement of TLR2, 4, 9, and Mincle which signal through MyD88, in the activation of the immune system by BCG [48,49,50,51], we observed that NFκB (which also induces TNFα) is an essential pathway for the induction of PGE2 and other tumor-promoting aspects of BCG-induced inflammation.