Additionally, a recent study indicated that CXCL8 and additional STAT3-dependent chemokines, CXCL1 and CXCL2) in activated bladder cancer microenvironment enhance the accumulation of neutrophils highlighting the pleiotropic character of inflammatory chemokines in shaping the bladder cancer microenvironment (Figure 6) [64]. This evidence concerns the gene CXCL2 and urinary bladder cancer.