The relative immaturity of hiPSC-derived cardiomyocytes hinders disease modelling of cardiomyopathies including metabolic syndromes, sarcomeric syndromes such as mutations of the sarcomere protein titin (TTN), disorders affecting cardiomyocyte contractility and cell cycle re-entry in mature cardiomyocytes in response to mitogens [125,128,129,130]. The gene discussed is TTN; the disease is metabolic syndrome.