MAPT and Alzheimer disease: The accumulation and aggregation of the amyloid-β peptide (Aβ) as extracellular deposits and the formation of intraneuronal aggregates of hyperphosphorylated tau protein (P-tau) as neurofibrillary tangles (NFTs) in the brain, associated by inflammation and oxidative stress processes [3] have been described as the pathological hallmarks of AD.