IRF2 and viral myocarditis: The miR-221/222 cluster was significantly induced during acute viral myocarditis caused by CVB3, which further decreased cardiac viral load by targeting E-twenty six 1/2 (ETS1/2), Interferon regulatory Factor 2 (IRF2), Bcl-2-like protein 11 (BCL2L11), TOX, Bcl-2-modifying factor (BMF), and CXC chemokine ligand 12 (CXCL12) [45].