The authors also report that inhibition of IL-1ß signaling reduces the number of CD-34+ micro-vessels in both, primary and bone metastatic MDA-MB-231-IV tumors in vivo using a preventative (treatment at day-3) and treatment schedule (treatment at day 7 post tumor cell injection) of anakinra (1 mg/kg/day) [55]. The gene discussed is IL1B; the disease is neoplasm.