APC and cancer: To explore whether differences in SNS acquisition rates could be explained by differences in proliferation rates, we calculated the cell doubling times in organoids with mutations in a single cancer-driver gene (Apc) and in organoids with mutations in three cancer-driver genes (AKP) using the formula (1) described in theSection 4.6 of Materials and Methods; the doubling times were 9.1 ± 0.4 and 8.2 ± 0.4 h, respectively (p = 0.08; not statistically significant).