C-X-C chemokine ligand 10 CXCL10, a main interferon (IFN)-γ inducible protein, now also recognized as a type I IFN inducible biomarker, plays a critical role in the pathogenesis and progression of several autoimmune diseases, including systemic sclerosis (SSc) [1,2] systemic lupus erythematosus (SLE) [3], juvenile idiopathic arthritis (JIA) [4] and inflammatory myopathy (IM) [5]. This evidence concerns the gene CXCL10 and systemic lupus erythematosus.