In the blood of SSc patients, the CXCL10 level, evaluated alone or in a composite score with CXCL11 (IFN-γ-inducible T-cell-a chemoattractant or I-TAC), is shown to be elevated in the presence of cardiac, lung, skin and muscle severe involvement [12,31]. Here, CXCL11 is linked to systemic sclerosis.