A common feature also contributing to the worse prognosis of SSc is the involvement of muscle tissue [14,15], either limited to peripheral muscle or extended to cardiomyopathy (id est, left ventricular cardiac dysfunction and or arrhythmia), both of which have been associated with increased CXCL10 levels in the blood [16,17,18]. The gene discussed is CXCL10; the disease is systemic sclerosis.