So, physical training in obese women does not only cause a reduction of BMI with an amelioration of global health state [36,37], but it is also efficacious in treating mild to moderate depression [38], inducing increased levels of anti-inflammatory cytokines and of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator Alpha (PGC1α), which reduces the synthesis of pro-inflammatory cytokines [35]. The gene discussed is PPARGC1A; the disease is major depressive disorder.