Similarly, we found a reduction in the hypoxia hallmark gene set (Figure 4A) and oxidative stress-induced senescence gene set (Figure S3C) in BATF-overexpressing CD8+ T cells, suggesting that these cells are more adapted to the hypoxic tumor microenvironment, resulting in better overall presence and survival in the tumor (Figure 3C). The gene discussed is CD8A; the disease is neoplasm.