However, it is important to note that BATF expression is not solely dependent on IL-21 signaling and can also be induced by T cell receptor (TCR) stimulation as well as other cytokines such as IL-12 [43,44,45]; thus, our study aims to provide one approach to enhance BATF expression and improve CD8+ T cell anti-tumor function. The gene discussed is IL21; the disease is neoplasm.